This is a gothic manga about a young man who keeps traveling to recover his 48 body parts deprived by demons. Daigo Kagemitsu, a local lord with an ambition to rule the world, promises to give his coming boy's body to 48 demons in exchange for fulfilling his ambition. Accordingly, the baby boy comes to the world lacking 48 body parts and is thrown into the river. Several years later, the boy named Hyakkimaru sets out on a journey to vanish demons to retrieve his lost body. Upon vanishing one demon, he retrieves one body part. Then, Hyakkimaru encounters Dororo, a sneak thief boy on his way and comes to make a journey with him. Wherever they go, they are constantly attacked by demons